| Autor: |
M.L.M. Lybeert, Elzbieta van de Steen-Banasik, Carien L. Creutzberg, Alfons C.M. van den Bergh, C.C. Wárlám-Rodenhuis, H Beerman, Wim L.J. van Putten, Ludy C.H.W. Lutgens, Peter C.M. Koper, Karin A.J. De Winter, Jan J. Jobsen, Mat van Lent |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
The Lancet. 355:1404-1411 |
| ISSN: |
0140-6736 |
| DOI: |
10.1016/s0140-6736(00)02139-5 |
| Popis: |
Summary Background Postoperative radiotherapy for International Federation of Gynaecology and Obstetrics (FIGO) stage-1 endometrial carcinoma is a subject of controversy due to the low relapse rate and the lack of data from randomised trials. We did a multicentre prospective randomised trial to find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma Methods Patients with stage-1 endometrial carcinoma (grade 1 with deep [≥50%] myometrial invasion, grade 2 with any invasion, or grade 3 with superficial [ Findings Analysis was done according to the intention-to-treat principle. Of the 715 patients, 714 could be evaluated. The median duration of follow-up was 52 months. 5-year actuarial locoregional recurrence rates were 4% in the radiotherapy group and 14% in the control group (p Interpretation Postoperative radiotherapy in stage-1 endometrial carcinoma reduces locoregional recurrence but has no impact on overall survival. Radiotherapy increases treatment-related morbidity. Postoperative radiotherapy is not indicated in patients with stage-1 endometrial carcinoma below 60 years and patients with grade-2 tumours with superficial invasion. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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