Fluorescent, Plasmonic, and Radiotherapeutic Properties of the 177Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells
| Autor: | Nallely Jiménez-Mancilla, Héctor Mendoza-Nava, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Flor de María Ramírez, Keila Isaac-Olivé, Myrna Luna-Gutiérrez, Guillermina Ferro-Flores |
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| Rok vydání: | 2017 |
| Předmět: |
Biomedical Engineering
Bombesin Nanoprobe Nanotechnology 02 engineering and technology Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics complex mixtures 01 natural sciences Fluorescence 0104 chemical sciences chemistry.chemical_compound chemistry Colloidal gold Dendrimer Cancer cell Biophysics Molecular Medicine Radiology Nuclear Medicine and imaging 0210 nano-technology hormones hormone substitutes and hormone antagonists Biotechnology Conjugate |
| Zdroj: | Molecular Imaging. 16:153601211770476 |
| ISSN: | 1536-0121 |
| DOI: | 10.1177/1536012117704768 |
| Popis: | The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic–photothermal, therapeutic, and radiotherapeutic potential of 177Lu–dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity (177Lu–DenAuNP–folate–bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP–folate–bombesin for optical imaging. After laser irradiation, the presence of the nanosystem in cells caused a significant increase in the temperature of the medium (46.8°C, compared to 39.1°C without DenAuNP–folate–bombesin, P < 0.05), resulting in a significant decrease in cell viability (down to 16.51% ± 1.52%) due to the 177Lu–DenAuNP–folate–bombesin plasmonic properties. After treatment with 17... |
| Databáze: | OpenAIRE |
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