Striking Effect of Polymer End-Group on C60 Nanoparticle Formation by High Shear Vibrational Milling with Alkyne-Functionalized Poly(2-oxazoline)s
| Autor: | Joachim F. R. Van Guyse, Reidar Lund, Sergey K. Filippov, Victor Retamero De La Rosa, Riet De Rycke, Richard Hoogenboom, Michiel De Bruyne |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Materials science Polymers and Plastics Organic Chemistry Alkyne Nanoparticle 02 engineering and technology Oxazoline Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Inorganic Chemistry End-group chemistry.chemical_compound Buckminsterfullerene chemistry Chemical engineering Materials Chemistry Solubility 0210 nano-technology |
| Zdroj: | ACS Macro Letters. 8:172-176 |
| ISSN: | 2161-1653 |
| DOI: | 10.1021/acsmacrolett.8b00998 |
| Popis: | Buckminsterfullerene (C-60) has a large potential for biomedical applications. However, the main challenge for the realization of its biomedical application potential is to overcome its extremely low water solubility. One approach is the coformulation with biocompatible water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form water-soluble C-60 nanoparticles (NPs). However, uniform and defined NPs have only been obtained via a thin film hydration method or using cyclodextrin-functionalized PAOx. Here, we report the mechanochemical preparation of defined and stable C-60:PAOx NPs by the introduction of a simple alkyne group as a polymer end-group. The presence of this alkyne bond is proven to be crucial in the mechanochemical synthesis of stable, defined sub-100 nm C-60:PAOx NPs, with high C-60 content up to 8.9 wt %. |
| Databáze: | OpenAIRE |
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