P387 THE PROGNOSTIC ROLE OF ST2L AND SST2 IN PATIENTS WHO UNDERWENT CAROTID PLAQUE ENDATERECTOMY: A FIVE–YEAR FOLLOW–UP STUDY

Autor: P Scicchitano, A Marzullo, F Cortese, A Ciccone, D Angiletta, R Pulli, F Massari, P Caldarola, M Ciccone
Rok vydání: 2022
Předmět:
Zdroj: European Heart Journal Supplements. 24
ISSN: 1554-2815
1520-765X
DOI: 10.1093/eurheartj/suac012.373
Popis: Background Soluble suppressor of tumorigenity (sST)–2 plasma concentrations are related to atherosclerosis. The aim of the study was to assess the prognostic impact of sST2 and its membrane–associated form (ST2L) in patients with carotid atherosclerotic plaque who underwent endarterectomy (CEA). Methods 82 consecutive patients (age range: 48–86 years) who underwent CEA were enrolled. Anthropometric, clinical, instrumental, and laboratory evaluations were gathered. Thirty–seven (45%) patients were symptomatic for cerebrovascular diseases. Patients underwent a five–year follow–up. Phone calls and the analysis of national and regional databases were adopted in order to evaluate the occurrence of the primary outcome (all–cause mortality). The populations was divided according to survival status. Results Statins were administered in 81% and 87.5% of survivors and non–survivors, respectively. sST2 levels were higher in non–survivors as compared to survivors (117.0 ± 103.9 vs 38.0 ± 30.0ng/mL, p 98.44 ng/mL as the best predictor for mortality. At one year follow–up, survival rate decreased up to 20% in patients with sST2 higher than the cut–off value. At multivariate regression analysis sST2 (HR: 1.012, 95% CI: 1.008–1.016, p Conclusions sST2 may act as independent prognostic determinant of all–cause mortality and symptomatic cerebrovascular diseases in patients with carotid atherosclerotic plaque who underwent CEA.
Databáze: OpenAIRE
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