Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

Autor:	James P. Sheridan, Kevin P. Baker, Scot A. Marsters, Audrey Goddard, Paul J. Godowski, Daryl T. Baldwin, Austin L. Gurney, Christa L. Gray, William I. Wood, Maya Skubatch, Robert M. Pitti, Avi Ashkenazi, Lakshmi Ramakrishnan
Rok vydání:	1997
Předmět:	Multidisciplinary Growth factor receptor Chemistry Immunology Decoy Receptor 1 5-HT5A receptor Decoy receptors Fas receptor Vascular endothelial growth inhibitor Insulin-like growth factor 1 receptor Cell biology Tumor Necrosis Factor Decoy Receptors
Zdroj:	Science. 277:818-821
ISSN:	1095-9203 0036-8075
Popis:	TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::24c2c25924c30e8ad29757aca6110d72 https://doi.org/10.1126/science.277.5327.818 Zobrazit plný text záznamu