Environmental fate of ceftiofur sodium, a cephalosporin antibiotic. Role of animal excreta in its decomposition
| Autor: | P. J. Hamlow, Jean M. Nappier, K. T. Koshy, Terry J. Gilbertson, G. L. Stahl, A. R. Cazers, Rex E. Hornish, Marc F. Kubicek, John L. Nappier, Gregory A. Hoffman, Prem S. Jaglan |
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| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | Journal of Agricultural and Food Chemistry. 38:890-894 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | The degradation of ceftiofur sodium, a wide-spectrum cephalosporin antibiotic, was studied in the urine and feces of cattle, in three soils, and in buffers of pH 5, 7, and 9. Photodegradation was also studied. Fortification of cattle feces with [14C]ceftiofur showed that it was quickly degraded to microbiologically inactive metabolites. Sterilization of the cattle feces inhibited the degradation of ceftiofur, which suggests that microorganisms or heat-labile substances may be responsible for the degradation. The t1/2 values of aerobic degradation of ceftiofur sodium in California, Florida, and Wisconsin soil were found to be 22.2, 49.0, and 41.4 days, respectively. Hydrolysis of ceftiofur, as measured by either HPLC or microbiological methods, was accelerated by increasing pH. The t1/2 values at pH 5, 7, and 9 were 100.3, 8.0, and 4.2 days, respectively, at 22 degrees C and dramatically increased at 47 degrees C. The photodegradation of ceftiofur, as determined by HPLC and a microbiological method, showed that after initial degradation for several days the rate of degradation was minimal, probably due to a protective film formed from degradation products. A major role for feces in the degradation of ceftiofur was observed, although other pathways of degradation such as soil, light, and water were also important. |
| Databáze: | OpenAIRE |
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