Dynamics of renin production by the juxtaglomerular and mesangial cells of single rat glomeruli after adrenalectomy
| Autor: | V. I. Fedorov, Yu. L. Perov |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Adrenalectomy medicine.medical_treatment Sodium chemistry.chemical_element General Medicine Juxtaglomerular apparatus Biology Golgi apparatus Plasma renin activity General Biochemistry Genetics and Molecular Biology symbols.namesake Endocrinology medicine.anatomical_structure chemistry Internal medicine Renin–angiotensin system medicine Organoid symbols Hormone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 87:104-107 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00833960 |
| Popis: | Six weeks after adrenalectomy rats without compensatory salt and hormones developed adrenal insufficiency, the renin activity in individual fragments of isolated glomeruli containing juxtaglomerular cells (JGC) was increased on average by 1.5 times, and renin-like activity (RLA) was found in fragments containing mesangial cells (MC). Signs of increased renin secretion (a decrease in the number of granules, marked development of the granular endoplasmic reticulum, Golgi complex, and microtubules) were observed in JGC. The corresponding organoids in MC were well developed but no granules were found. After 8–12 weeks, on restoration of the 11-HCS and sodium levels in the plasma, renin activity was restored to normal in JGC, RLA disappeared in MC, and both types of cells recovered their original ultrastructure. The reserve role of MC as a source of renin-like substances was confirmed. |
| Databáze: | OpenAIRE |
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