Development of Overt Proteinuria in the Munich Wistar Fro[Combining Diaeresis]mter Rat Is Suppressed by Replacement of Chromosome 6 in a Consomic Rat Strain
| Autor: | Angela Schulz, Monika Stoll, Judith Weiss, Peter Kossmehl, Anika Sietmann, Markus Wehland, Maria Schlesener, Daniela Grimm, Jens R. Nyengaard, Norbert Wendt, Reinhold Kreutz, Jonna Hänsch |
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| Rok vydání: | 2007 |
| Předmět: |
Nephrology
medicine.medical_specialty Kidney Proteinuria Locus (genetics) General Medicine Quantitative trait locus Biology Pathogenesis Excretion medicine.anatomical_structure Endocrinology Internal medicine cardiovascular system medicine Albuminuria cardiovascular diseases medicine.symptom circulatory and respiratory physiology |
| Zdroj: | Journal of the American Society of Nephrology. 18:113-121 |
| ISSN: | 1046-6673 |
| Popis: | In a cross between the Munich Wistar Fromter (MWF) rat and spontaneously hypertensive rats (SHR), a major quantitative trait locus (QTL) was identified on rat chromosome 6 (RNO6) that demonstrated the strongest linkage to albuminuria among several QTL identified. The QTL represented the only locus that is linked to both early-onset albuminuria and increased renal interstitial fibrosis in adult animals. A consomic MWF-6 SHR strain in which chromosome 6 from SHR was introgressed into the MWF background therefore was generated to test the relevance of this QTL. Phenotype analysis at 8 wk of age revealed that early onset of albuminuria in MWF with a 55-fold elevation of urinary albumin excretion compared with SHR ( P SHR . Time-course analysis until week 24 demonstrated only a moderate increase of urinary albumin excretion in MWF-6 SHR , whereas MWF reached levels in the nephrotic range (16.6 ± 3.5 versus 162.6 ± 16.0 mg/24 h; P SHR compared with MWF ( P SHR demonstrated overt proteinuria (354.6 ± 37.6 versus 48.8 ± 13.2; P SHR compared with MWF ( P |
| Databáze: | OpenAIRE |
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