| Autor: |
David E. Cummings, Jeffrey A. Kant, Gerald R. Crabtree, Albert J. Fornace, C M Comeau |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
Journal of Biological Chemistry. 259:12826-12830 |
| ISSN: |
0021-9258 |
| DOI: |
10.1016/s0021-9258(18)90821-5 |
| Popis: |
The gamma chain of human fibrinogen exists in 2 nonallelic forms, gamma A and gamma B, which differ only in their carboxyl termini. We have found that only one genomic locus exists for gamma-fibrinogen and that the gamma A and gamma B chains arise by alternate mRNA splicing near the 3' end of this gene. In contrast to the rat gamma B mRNA which is produced by alternate splicing with identical polyadenylation sites, human gamma B is produced when the eighth intervening sequence remains unspliced and a polyadenylation signal within this intron is used. The new carboxyl terminus is 16 amino acids longer than the gamma A protein, and although there is only minimal homology between the rat and human carboxyl termini they share a very high proportion of acidic amino acids. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
