Coronary heart disease outcomes among chronic opioid and cyclooxygenase-2 users compared with a general population cohort
| Autor: | John I. Wurzelmann, Wendy J. Carman, Shuhua Su, Suzanne F. Cook, Andrew T. McAfee |
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| Rok vydání: | 2011 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Epidemiology business.industry Incidence (epidemiology) Population General Population Cohort Retrospective cohort study medicine.disease Confidence interval Internal medicine Cohort Cardiology Medicine Pharmacology (medical) Myocardial infarction business education Cohort study |
| Zdroj: | Pharmacoepidemiology and Drug Safety. 20:754-762 |
| ISSN: | 1053-8569 |
| Popis: | BACKGROUND We estimated the incidence of myocardial infarction (MI) and coronary revascularization (CR) among users of chronic opioid therapy (COT) and compared risks across categories of morphine-equivalent doses of COT and comparator cohorts. METHODS We conducted a retrospective claims-based study using de-identified data from a commercially insured population. A cohort of 148,657 adult users of COT, a matched cohort of the general population, and three cohorts of users of chronic cyclooxygenase-2 (COX-2) inhibitor therapy totaling 122,810 were identified. Incidence rates and incidence rate ratios (IRRs) of MI and MI/CR were estimated. RESULTS Adjusted IRRs for MI ranged from 1.21 (95% confidence interval [95%CI], 1.02-1.45) among those receiving low COT doses to 1.89 (95%CI, 1.54-2.33) among those receiving high doses compared with those receiving very low doses, averaging |
| Databáze: | OpenAIRE |
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