An 8 week prospective study on the relationship between major depressive episode and serum brain derived neurotrophic factor in a Nigerian tertiary hospital

Autor: Frances Adiukwu, Jude U. Ohaeri, Princewill Chukwuemeka Stanley
Rok vydání: 2019
Předmět:
Zdroj: Neurology, Psychiatry and Brain Research. 32:42-47
ISSN: 0941-9500
DOI: 10.1016/j.npbr.2019.03.007
Popis: Background Current views on the etiology of Major Depressive Diorder(MDD) emphasizes environmental and biological interplay. Recent studies have implicated reduction in Brain Derived Neurotrophic Factor (BDNF) in the pathophysiology and as a biomarker of major depression (Neurotrophin Hypothesis of Depression). This study aimed at showing that the Neurotrophin hypothesis of depression is relevant in the pathophysiology of Major Depressive Episode in Southern Nigeria. Methods Consecutive consenting patients diagnosed with Major Depressive Episode (MDE) using the Structured Clinical Interview for DSM (SCID) and age and sex matched controls were enrolled into this study. Serum BDNF was measured prior to commencement of treatment as baseline and 8 weeks after treatment. Depression severity was rated with the Hamilton Depression Rating Scale (HAM-D) and Patient Health Questionnaire (PHQ-9). Results Seventy-five cases and 75 age and sex matched controls were recruited. The mean ± SD of serum BDNF of depressed patients (26.09 ng/ml ± 1.96) was significantly lower than those of age and sex matched controls (28.13 ng/ml ± 1.47) P Limitations This was a single center study with a high drop-out rate. Conclusion The result of this study adds to the mounting evidence in support of the neurotrophin hypothesis of depression.
Databáze: OpenAIRE
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