Myocardial oxygen utilization after reversible global ischemia
| Autor: | James T. Streicher, Daniel K. Bogen, Joseph E. Bavaria, Mark B. Ratcliffe, Edmunds Lh, Satoshi Furukawa, Gerhard Kreiner |
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| Rok vydání: | 1990 |
| Předmět: |
Pulmonary and Respiratory Medicine
Myocardial ischemia business.industry Myocardial Reperfusion Injury Ischemia Apparent oxygen utilisation chemistry.chemical_element medicine.disease Oxygen Coronary heart disease Wall stress chemistry Anesthesia medicine Surgery cardiovascular diseases Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 100:210-220 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)35560-6 |
| Popis: | We tested in 20 sheep the hypothesis that oxygen consumption increases after reversible, global myocardial ischemia. Left ventricular oxygen consumption before and after 25 minutes of warm (37 degrees C) global ischemia was linearly related to a function (integral) of left ventricular circumferential systolic wall stress, altered by changing afterload. The relation is expressed in the two regression equations: LVO2 (preischemic) = 1.06.SSI + 16.8 (n = 129; r = 0.79); LVO2 (postischemic) = 4.35.SSI + 5.6 (n = 89; r = 0.65). The fourfold increase in slope (4.35 versus 1.06) indicates (p = 0.0001) a massive increase of oxygen consumption in postischemic, globally "stunned" myocardium. The inferences are that globally stunned myocardium causes severe impairment of oxygen utilization efficiency, and increased vulnerability to further ischemia if coronary vessels are diseased. |
| Databáze: | OpenAIRE |
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