Anaplastic Large Cell Lymphoma in a Human Immunodeficiency Virus-Positive Patient with Cytologic Findings in Bladder Wash
| Autor: | Lawrence De Renne, William L. Marsh, Sedigheh Keyhani-Rofagha, Daniela M. Proca |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Urinary bladder CD30 medicine.diagnostic_test business.industry Urinary system General Medicine medicine.disease Pathology and Forensic Medicine Lymphoma medicine.anatomical_structure hemic and lymphatic diseases Cytology Biopsy medicine Null cell business Anaplastic large-cell lymphoma |
| Zdroj: | Acta Cytologica. 52:83-86 |
| ISSN: | 1938-2650 0001-5547 |
| DOI: | 10.1159/000325439 |
| Popis: | BACKGROUND Anaplastic large cell lymphoma (ALCL) (Ki-1/CD-30 positive) is an uncommon lymphoproliferative disorder that may be of T cell or null cell type. ALCL has been reported in fine needle aspirations of lymph nodes and pleural or peritoneal fluid cytology. In human immunodeficiency virus (HIV)-positive patients, ALCL appears to be more common and run a more aggressive course. CASE A 39-year-old black man, seropositive for HIV, presented with acute renal failure secondary to bilateral ureteral obstruction by a pelvic mass involving the urinary bladder. Bladder wash cytology and subsequent biopsy of the mass were diagnostic of ALCL. The ALCL was CD30+ and null cell type, with negative CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD45, CD79a, ALK-1, granzyme B, cytokeratin (AE1/AE3), placental alkaline phosphatase (PLAP) and S-100. The patient expired 9 months after the diagnosis, despite aggressive therapy. CONCLUSION This is a rare occurrence of ALCL (CD 30 positive, null cell type) in the urinary bladder in an HIV+ patient. Presumptive diagnosis was made by bladder wash cytology and subsequently confirmed by biopsy. Urinary cytologic examination is a useful diagnostic tool. In HIV+/immunosuppressed patients with urinary symptoms and an obstructive mass, ALCL should be considered in the differential diagnosis. |
| Databáze: | OpenAIRE |
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