Condensed Clustered Iron Oxides for Ultrahigh Photothermal Conversion and In Vivo Multimodal Imaging
| Autor: | Aristides Bakandritsos, Peter Keša, Konstantinos Avgoustakis, Athina Angelopoulou, Jan Pankrác, Vít Herynek, Katerina Polakova, Argiris Kolokithas-Ntoukas, Vasilios Georgakilas, Jan Belza, Ondrej Malina, Radek Zboril |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Passivation Biocompatibility Photothermal effect Iron oxide Nanotechnology 02 engineering and technology Nanoengineering Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Nanomaterials chemistry.chemical_compound chemistry Nanomedicine General Materials Science 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 13:29247-29256 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.1c00908 |
| Popis: | Magnetic iron oxide nanocrystals (MIONs) are established as potent theranostic nanoplatforms due to their biocompatibility and the multifunctionality of their spin-active atomic framework. Recent insights have also unveiled their attractive near-infrared photothermal properties, which are, however, limited by their low near-infrared absorbance, resulting in noncompetitive photothermal conversion efficiencies (PCEs). Herein, we report on the dramatically improved photothermal conversion of condensed clustered MIONs, reaching an ultrahigh PCE of 71% at 808 nm, surpassing the so-far MION-based photothermal agents and even benchmark near-infrared photothermal nanomaterials. Moreover, their surface passivation is achieved through a simple self-assembly process, securing high colloidal stability and structural integrity in complex biological media. The bifunctional polymeric canopy simultaneously provided binding sites for anchoring additional cargo, such as a strong near-infrared-absorbing and fluorescent dye, enabling in vivo optical and photoacoustic imaging in deep tissues, while the iron oxide core ensures detection by magnetic resonance imaging. In vitro studies also highlighted a synergy-amplified photothermal effect that significantly reduces the viability of A549 cancer cells upon 808 nm laser irradiation. Integration of such-previously elusive-photophysical properties with simple and cost-effective nanoengineering through self-assembly represents a significant step toward sophisticated nanotheranostics, with great potential in the field of nanomedicine. |
| Databáze: | OpenAIRE |
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