Simultaneous Quantification of Paclitaxel and Vinorelbine Encapsulated in Theranostic Nanosized Liposomes

Autor:	Aysegul Dogan, Emirhan Nemutlu, Merve Karpuz, A. Yekta Ozer, Mine Silindir-Gunay
Rok vydání:	2021
Předmět:	Liposome Cancer Treatment method Vinorelbine medicine.disease Analytical Chemistry Health problems chemistry.chemical_compound Paclitaxel chemistry Drug delivery medicine Hplc method Biomedical engineering medicine.drug
Zdroj:	Journal of Analytical Chemistry. 76:742-748
ISSN:	1608-3199 1061-9348
Popis:	Cancer is one of the major health problems with an increasing incidence and mortality. Although imaging and effective treatment methods are critical issues to prevent cancer mortality, they are inadequate. Therefore, new approaches including combined treatment protocol and nanosized drug delivery theranostic systems are being investigated because of the deficiency of conventional cancer imaging and treatment methods in clinics. Liposomes attract attention in cancer imaging and treatment due to their advantages. In this study, an HPLC method was developed for simultaneous quantification of paclitaxel (PCX) and vinorelbine tartarate (VNB) in co-drug encapsulated theranostic nanosized liposome formulations as an effective cancer imaging and treatment agent. The method was validated according to ICH Analytical Method Validation guideline. According to the validation results, the method was found to be linear (r > 0.999), accurate (bias ≤ 1.8), precise (RSD ≤ 1.8%) and robust (p > 0.05). The developed method was successfully applied to the quantification of PCX and VBN in liposomes for encapsulation efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::246a51d47c557824e9345a6154ba9d29 https://doi.org/10.1134/s1061934821060034 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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