Novel cytotoxic icetexane diterpenes from Premna latifolia Roxb

Autor:	Sistla Ramakrishna, K. Suresh Babu, V. Lakshma Nayak, M. Suri Appa Rao, G. Suresh, V. Rama Subba Rao
Rok vydání:	2011
Předmět:	biology Stereochemistry Premna Organic Chemistry Fractionation biology.organism_classification Biochemistry Terpenoid Hexane chemistry.chemical_compound chemistry visual_art Drug Discovery visual_art.visual_art_medium Cytotoxic T cell Bark Diterpene Cytotoxicity
Zdroj:	Tetrahedron Letters. 52:1273-1276
ISSN:	0040-4039
Popis:	Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes ( 1 – 3 ). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1 – 3 were also evaluated for the cytotoxicity against the cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10 and ACHN). Compounds 1 and 2 displayed potent cytotoxic activity against HT-29 and Hep-G2 cell lines with IC 50 values of 0.04 and 0.18 μg/mL, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::246982fbca0e33f325add6a3ae8a657e https://doi.org/10.1016/j.tetlet.2011.01.025 Zobrazit plný text záznamu Full Text from ScienceDirect