Multipotential Secondary Metabolites from Nocardiopsis dassonovillei of Marine Actinomycetes and their In Silico studies

Autor:	K. Dinesh Kumar, J. Vigneshwari J. Vigneshwari, A. Gnanasekaran A. Gnanasekaran, V. Selvamani V. Selvamani, P. K. Senthilkumar
Rok vydání:	2023
Předmět:	Drug Discovery Agronomy and Crop Science Biotechnology
Zdroj:	Biosciences Biotechnology Research Asia. 20:173-187
ISSN:	2456-2602 0973-1245
DOI:	10.13005/bbra/3079
Popis:	Actinomycetes are one of the important secondary metabolite producers. Researchers focused on the exclusive marine areas for isolation and identification of marine actinomycetes. The present study focused on the isolation and identification of Nocardiopsis dassonovillei (ON627850) from TS Pettai region. The potential strainTSP1 showed effective antibacterial activity against Haemophilus influenza. TSP1 isolates showed IC50 value of 75.22 μg/ml effective antioxidant activity determined by DPPH assay. Cytotoxicity assay results were noted for the ethyl acetate extract of TSP1 screened against oral cancer cell lines (KB). The spectral characterization studies of UV, FT-IR and GC-MS results identified the compound 2,4-di-tert-butylphenol. The multi-potential 2,4-di-tert-butylphenol compound finally docked with KB cell lines protein for drug discoveries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2469500c6f20395ec3166ceb6d1b249a https://doi.org/10.13005/bbra/3079 Zobrazit plný text záznamu