Antibacterial activity of ethanol extract of the defatted seed and seed coat of Moringa oleifera
| Autor: | Elijah I. Ohimain, Douye V. Zige, Philip C. N. Alikwe |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | IOSR Journal of Pharmacy and Biological Sciences. 8:38-41 |
| ISSN: | 2278-3008 2319-7676 |
| DOI: | 10.9790/3008-0813841 |
| Popis: | Recent interest in infectious disease threats to clinical microbiology and public health is the emergence of pathogens with high multidrug resistance especially to available newer broad spectrum antibiotics that is cost prohibitive and are not even within the reach of the poor, making infectious diseases a global burden and therefore prompting the need for the search of potential plants in the treatment of diseases. However antibacterial activity of ethanol extract of Moringa oleifera defatted seed (MODS) and seed coat (MOSC) was conducted. Paper disc diffusion method was used to assess the effect of the extracts on Pseudomonas aerogenosa, Escherichia coli, Klebsiella sp, Salmonella Typhi, Proteus mirabilis, all the examined extract showed varying degrees of antibacterial activities against the selected pathogens. Highest inhibitory effect was observed in Proteus mirabilis (19mm) following Salmonella Typhi (16mm) with the Moringa oleifera seed extract, these strains S. Typhi and Proteus mirabilis were resistant to ethanol extract of Moringa oleifera seed coat along with their respective minimum inhibitory concentration (MIC) values ranging from extract on the test isolates ranges from a 0.1mg/ml- 100mg/ml concentration. This study has shown that the ethanol extract of Moringa oleifera seed possess some degree of antimicrobial activity than ethanol extract of the seed coat and could be a valuable Drug in the treatment of infections caused by the test organisms especially at high dose, therefore these findings support the traditional use of the plant in the treatment of different infections in the area. |
| Databáze: | OpenAIRE |
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