GC-MS-FID and potentiation of the antibiotic activity of the essential oil of Baccharis reticulata (ruiz & pav.) pers. and α-pinene
| Autor: | Ana Cristina Albuquerque da Silva, José Maria Barbosa-Filho, Jaime Ribeiro-Filho, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Wanderlei do Amaral, Luiz Everson da Silva, Débora Feitosa Muniz, Priscilla Ramos Freitas, Cristina Rodrigues dos Santos Barbosa, Cícera Datiane de Morais Oliveira-Tintino, Cícero Deschamps, Ana Carolina Justino de Araújo, Saulo R. Tintino, Natanael Teles Ramos de Lima, Camila Confortin |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Pinene biology Traditional medicine 010405 organic chemistry Baccharis biology.organism_classification 01 natural sciences 0104 chemical sciences law.invention chemistry.chemical_compound Minimum inhibitory concentration chemistry law medicine Gentamicin Antibacterial activity Agronomy and Crop Science Bacteria Norfloxacin Essential oil 010606 plant biology & botany medicine.drug |
| Zdroj: | Industrial Crops and Products. 145:112106 |
| ISSN: | 0926-6690 |
| DOI: | 10.1016/j.indcrop.2020.112106 |
| Popis: | The genus Baccharis (Asteraceae) demonstrated the presence of compounds with antibacterial, antifungal and antioxidant activities. Because of the increasing rates of antimicrobial resistance, adequate treatment of infections caused by Gram-negative bacteria has become challenging. The objective of the present study was evaluate the antibacterial and antibiotic-modifying activity of the essential oil obtained from Baccharis reticulata (Ruiz & Pav.) Pers. and the compound α-pinene against Pseudomonas aeruginosa and other multiresistant bacteria. An analysis by gas chromatography associated with mass spectrometry (GC/MS) revealed the presence of dilapiol (33.8 %), α-pinene (31.7 %) and β-pinene (9.4 %) as major components of the oil. The determination of the Minimum Inhibitory Concentration (MIC) revealed that the oil has antibacterial activity against S. aureus only. However, the oil potentiated the norfloxacin and gentamicin against all strains evaluated. Also, α-pinene increased the activity of norfloxacin against E. coli, as well as potentiated the activity of norfloxacin and gentamicin against S. aureus. Therefore, the authors conclude that the essential oil of B. reticulata, as well as the compound α-pinene, have antibacterial and antibiotic-modulating activities that make them useful in the development of new weapons against bacterial resistance. |
| Databáze: | OpenAIRE |
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