A efficient protocol for the synthesis of thioamides in [DBUH][OAc] at room temperature
| Autor: | Hui Zheng, Xian-Ting Cao, Pengfei Zhang, Hui-Yong Yang, Li Qiao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry General Chemical Engineering Aryl Salt (chemistry) chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Sulfur Combinatorial chemistry Sodium sulfide 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Ionic liquid |
| Zdroj: | RSC Advances. 8:170-175 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c7ra11259a |
| Popis: | A novel, simple and eco-friendly method to synthesize thioamides from aryl nitriles and sodium sulfide (Na2S·9H2O) catalyzed by 1,8-diazabicyclo[5,4,0]undec-7-enium acetate ([DBUH][OAc]) ionic liquid (IL) at room temperature was developed in this paper. In this reaction, readily available inorganic salt (Na2S·9H2O) serves as the sulfur source, and various functional groups of aryl nitriles were well tolerated at room temperature. In addition, the products were easily separated from the IL which could be reused at least five times without considerable loss of its activity and applied in the green, concise synthesis of ethionamide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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