Targeted Antitumor Drug Delivery to Glioblastoma Multiforme Cells

Autor: E. E. Tyagunova, R. K. Kostin, T. I. Shlapakova, D. A. Danilova
Rok vydání: 2021
Předmět:
Zdroj: Russian Journal of Bioorganic Chemistry. 47:376-379
ISSN: 1608-330X
1068-1620
DOI: 10.1134/s1068162021020254
Popis: Currently, brain tumors are becoming more common and their clinical picture is aggravated by serious complications. According to the statistics of the World Health Organization (WHO), glioblastoma multiforme (GBM) is the most aggressive brain tumor with high invasive capacity, which is difficult to predict, while most cases are sporadic and do not have a genetic predisposition. Since GBM cannot be simply eliminated by operation, drug availability to penetrate the blood-brain barrier (BBB) is greatly complicated and the accumulation of chemotherapeutics in GBM is low, the therapeutic effects are poor, and there is a strong need to develop various approaches to deliver drugs to the CNS. The vector delivery of antitumor drugs is becoming more relevant, as well as various drugs that change the permeability of the BBB to facilitate the passage of antitumor drugs and their greater specific accumulation in tumor cells. The reversible short-term opening of tight junctions in brain endothelial cells and the effect on the functioning of active outflow transport systems represented by ATP-binding cassette transporters have been under serious research focus for the last few years in order to develop the appropriate drug delivery to the brain to treat GBM. A particularly promising direction in this area is the development of drugs that do not violate the integrity of the BBB and do not require the introduction of additional drugs to improve their activity and permeability. Active delivery nanoparticles are more effective than passively directed nanoparticles. Drugs that induce changes in the permeability of the BBB for various nanoparticles and other anticancer drugs are very effective, but they have a number of disadvantages and can cause complications. Therefore, before using these substances, all the risks should be evaluated, the controllability of this process, and the effectiveness of the drugs that inhibit ongoing reactions. It is considered safer and more effective to use active targeted drug delivery, which uses the attachment of site-specific ligands to the surface of nanoparticles.
Databáze: OpenAIRE
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