Analysis of NMDA-dependent voltage bistability in thin dendritic compartments
| Autor: | Maciej T. Lazarewicz, Douglas A. Coulter, Gregory C. Carlson, Leif H. Finkel, Chyze-Whee Ang |
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| Rok vydání: | 2006 |
| Předmět: |
Membrane potential
Materials science Quantitative Biology::Neurons and Cognition Bistability Cognitive Neuroscience Conductance Gating Computer Science Applications Quantitative Biology::Subcellular Processes nervous system Maximum diameter Artificial Intelligence Control theory Biophysics NMDA receptor Voltage |
| Zdroj: | Neurocomputing. 69:1025-1029 |
| ISSN: | 0925-2312 |
| Popis: | We analyze the parameter ranges under which the voltage in a dendritic cable model exhibits bistability. We find (1) the magnitude of NMDA and GABA conductances limit the maximum cable diameter for which the system is bistable. For the investigated parameter ranges, the maximum diameter scales linearly with conductance. (2) NMDA current in the absence of GABA inhibition is not capable of generating bistability. (3) For small cable diameters ([email protected]), the bistable equilibra of membrane potential occur at -33.3 and -79.2mV, independent of the NMDA and GABA conductance. |
| Databáze: | OpenAIRE |
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