| Autor: |
Nazarii Sabat, Weiping Zhou, Vincent Gandon, Xavier Guinchard, Guillaume VINCENT |
| Rok vydání: |
2022 |
| Popis: |
The direct dearomative addition of arenes to the C3-position of unprotected indoles is reported under operationally simple conditions with triflic acid at room temperature. The present regioselective hydroarylation is a straightforward manner to gen-erate an electrophilic indole at the C3-position without the need to introduce a deactivating acetyl group on the indolic nitrogen as in previously reported strategies. This atom economy method delivers biologically relevant 3-aryl indolines and 3,3-spiroindolines in high yields and regioselectivities from both intra and intermolecular processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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