Animal Models for Medication Development and Application to Treat Fetal Alcohol Effects
| Autor: | Susan Barron, L. Fields, A. Hawkey, J.M. Littleton |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pregnancy
medicine.medical_specialty business.industry Offspring Prenatal ethanol Pharmacology medicine.disease 030227 psychiatry 03 medical and health sciences Fetal alcohol 0302 clinical medicine Prenatal Exposure Delayed Effects Intervention (counseling) medicine business Intensive care medicine 030217 neurology & neurosurgery |
| DOI: | 10.1016/bs.irn.2016.02.002 |
| Popis: | Ethanol consumption during pregnancy can have lifelong consequences for the offspring, their family and society. Fetal alcohol spectrum disorders (FASD) include a range of physical and behavioral effects with the most significant impact occurring as a result of the effects of ethanol on the developing central nervous system (CNS). To date, there are no FDA approved drugs that have been tested that prevent/reduce or specifically treat the symptoms of FASD. There are several promising lines of research from rodent models aimed at reducing the neurotoxic effects of ethanol on the developing CNS or in treating the resulting behavioral impairments but these have not yet moved to clinical testing. The current review discusses some of the most promising targets for intervention and provides a review of the past and ongoing efforts to develop and screen pharmacological treatments for reducing the effects of prenatal ethanol exposure. |
| Databáze: | OpenAIRE |
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