Total Synthesis of Cyclic Octapeptide Reniochalistatin E
| Autor: | Wenwei Han, Xia Zhao, Mingyue Bai, Yulei Li, Yanyun Gao, Qi Chang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Stereochemistry Reniochalistatin E Fmoc chemistry Total synthesis Plant Science General Chemistry Solution synthesis Carbon-13 NMR 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences Amino acid Phase (matter) |
| Zdroj: | Chemistry of Natural Compounds. 54:1131-1134 |
| ISSN: | 1573-8388 0009-3130 |
| Popis: | The total synthesis of a naturally occurring proline-enriched cyclic octapeptide, reniochalistatin E, from a marine sponge, where all the amino acids have the L-configuration, was reported. The reniochalistatin E was synthesized by applying a two-step solid-phase/solution synthesis strategy. The linear octapeptide was assembled by standard Fmoc chemistry on the solid phase, and subsequently cyclization was achieved by a solution method. The final product was purified by a preparative RP-HPLC system, and its structure was identified by HR-QTOF-MS, and 1H and 13C NMR. |
| Databáze: | OpenAIRE |
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