Validation of the non-alcoholic fatty liver disease activity score
| Autor: | Stephen A. Harrison, Janet Shaw, C. Stauch, M. Hjelkrem |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology Hepatology medicine.diagnostic_test business.industry Fatty liver Gastroenterology nutritional and metabolic diseases Retrospective cohort study medicine.disease digestive system digestive system diseases Predictive value of tests Internal medicine Biopsy Severity of illness medicine Pharmacology (medical) Steatosis Steatohepatitis business Kappa |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 34:214-218 |
| ISSN: | 0269-2813 |
| DOI: | 10.1111/j.1365-2036.2011.04695.x |
| Popis: | Aliment Pharmacol Ther 2011; 34: 214–218 Summary Background The non-alcoholic fatty liver disease (NAFLD) activity score (NAS) is a scoring system designed by the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network (CRN) to encompass the spectrum of NAFLD and evaluate histological changes. However, the NAS and the correlation between the NAS and a diagnosis of NASH have not been validated outside the NASH CRN. Aim To validate the NAS outside the NASH CRN. Methods This study retrospectively examined liver biopsies from adults with NAFLD or steatohepatitis obtained from January 2003 to May 2010. Biopsy specimens were evaluated twice in a blinded manner by a single hepatopathologist, once to determine a diagnosis (steatohepatitis or steatosis/not-steatohepatitis), and a second time to determine the NAS. Results A total of 386 liver biopsies were evaluated. Mean age of patients at time of biopsy was 49.9 ± 10.2 years. NASH was found in 51% of the patients. For NAS ≥5 as a diagnosis of steatohepatitis and NAS |
| Databáze: | OpenAIRE |
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