Fate of Biodegradable DL-Lactic Acid Oligomer Microspheres in the Articulus
| Autor: | Masato Nishide, Yoshito Ikada, Shigeru Kamei, Yasuhiko Tabata, Susumu Tamai, Yoshinori Takakura |
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| Rok vydání: | 1999 |
| Předmět: |
Lagomorpha
Chromatography Polymers and Plastics Biocompatibility Molecular mass biology Bioengineering Biodegradation biology.organism_classification 030226 pharmacology & pharmacy Oligomer Fluorescence Lactic acid Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Materials Chemistry Drug carrier Biomedical engineering |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 14:385-398 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/088391159901400502 |
| Popis: | The objective of the present study was to investigate the biodegradation and tissue responses of dl-lactic acid oligomer microspheres in the knee articulus. Different-sized microspheres containing a fluorescent dye were prepared from oligomers with different molecular weights (Mw) by a solvent evaporation method. Following intra-articular injection into the kneejoint of rabbits, the microspheres were localized at the popliteal fat tissue, irrespective of the microsphere size and oligomer Mw. When degradation of the microspheres injected intra-articularly was evaluated based on the decrease in the fluorescent intensity of microspheres remaining, the microspheres were degraded with time to finally disappear in the articular cavity. The degradation periods of microsphere prepared from 3,000, 5,600, and 7,000 Mw oligomers were 5, 10, and 17 days, respectively, whereas no size dependence on microsphere degradation was observed. No inflammatory response to the microspheres by the synovial tissue was observed; however, there was a temporary increase in the number of white blood cells in the articular cavity, irrespective of the microsphere size. |
| Databáze: | OpenAIRE |
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