The Effect of a Single Heating Treatment on Laboratory Mice Behavior, Adult Neurogenesis, and the Expression of Heatshock Protein HSP-70
| Autor: | N. A. Ogienko, Galina Pavlova, Inga I. Poletaeva, I. G. Lilp, David G. Garbuz, A. V. Revishchin, O. V. Perepelkina |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Chemistry 030302 biochemistry & molecular biology Cell Neurogenesis General Biochemistry Genetics and Molecular Biology Open field 03 medical and health sciences medicine.anatomical_structure Endocrinology Internal medicine Forebrain medicine General Agricultural and Biological Sciences 030304 developmental biology General Environmental Science |
| Zdroj: | Moscow University Biological Sciences Bulletin. 74:86-91 |
| ISSN: | 1934-791X 0096-3925 |
| Popis: | Male hybrid mice (F1 CBA × C57BL/6J) were kept for 1.5 h at 39.5°С. In cognitive tests (extrapolation and puzzle-box elementary logic task solution), mice of the experimental groups (after exposure to an elevated temperature) solved the tasks more quickly and more successfully, while their activity in the “small open field” (in which no stress-inducing stimuli were present) and in the Porsolt test (unescapable swimming) was higher than in control mice. In separate experiments, the temporary impairment in the adult neurogenesis (the decrease of new cell numbers detected immunо-histochemically by the marker Ki67) after elevated temperature exposure was demonstrated in both the subgranular area of dentate fascia and in the subventricular proliferative zone of the forebrain. The heating treatment was accompanied by the increase of HSP-70 expression at the time point 3 h after the treatment, while no differences from control were found after 24 h. |
| Databáze: | OpenAIRE |
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