| Autor: |
Shahenul Islam, Tran Quang De, Shamima Akhter, Rahen Mahmuda, Sukumar Bepary, Pranoy Saha, Khadija Akhter Poly, Negar Sultana Shoshi |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Can Tho University Journal of Science. 12 |
| ISSN: |
2615-9422 |
| DOI: |
10.22144/ctu.jen.2020.027 |
| Popis: |
Resorcinol with its two hydroxyl groups was derivatized in laboratory to observe the anti-inflammatory potential in vitro. Subsequently in silico docking analysis was done for observing the binding modes in cyclooxygenase enzyme to have idea about the subsequent possible developments. At the doses of 200 mg/ml and 400 mg/ml. the compounds showed the anti-inflammatory property, where 02 offered dose dependent 51% and 70% of inhibition of heat induced hemolysis respectively. The scaffold thus poses as an interesting pharmacophore suitable for lead generation for the inflammatory disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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