Lipoprotein lipase activity and protein oxidative damage are increased in brain by age but not by fish oil ingestion
| Autor: | Argelia Garrido, Cecilia I. Lopez |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Lipoprotein lipase Nutrition and Dietetics food.ingredient Endocrinology Diabetes and Metabolism Coconut oil Glutathione Biology Fish oil medicine.disease_cause chemistry.chemical_compound Endocrinology food chemistry Glutamine synthetase Internal medicine medicine Ingestion Oxidative stress Polyunsaturated fatty acid |
| Zdroj: | Nutrition Research. 18:519-531 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/s0271-5317(98)00039-6 |
| Popis: | Dietary fish oil containing n-3 polyunsaturated fatty acids (PUFA n-3) plays a protective role in the prevention of cardiovascular diseases. However they may potentially produce a negative health effect because their susceptibility to free radical-induced oxidative damage. This effect would be particularly significant during aging. In order to investigate if fish oil ingestion is associated with elevation of oxidative damage in the brain, we compared in rats fed 3–4 months (young) or 18–22 months (aged), the effect of three diets: a cereal based diet (N), and a modified cereal based diet supplemented with either 10 wt % fish oil (FO) or 10 wt % coconut oil (CO). We studied the influence of these diets in the fatty acid composition, in the lipoprotein lipase (LPL) and glutamine synthetase (GS) activities, and in the concentration of protein carbonyls and reduced glutathione (GSH) of the rat brains. Results showed that FO may regulate the brain lipid composition of young and aged rats, not affecting the oxidative level of cytosolic proteins. On the other hand, brains from aged rats exhibit increased protein oxidative damage and LPL activity when compared to young rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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