Rapid Antibiofilm Effect of Ag/ZnO Nanocomposites Assisted by Dental LED Curing Light against Facultative Anaerobic Oral Pathogen Streptococcus mutans
| Autor: | Zhao Li, Shilei Wang, Xiangyu Liu, Zhong Lu, Hao Yang, Qiaomu Huang |
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| Rok vydání: | 2019 |
| Předmět: |
Nanocomposite
biology Chemistry 0206 medical engineering Biomedical Engineering Biofilm 02 engineering and technology 021001 nanoscience & nanotechnology biology.organism_classification 020601 biomedical engineering Streptococcus mutans Nanomaterials Microbiology Biomaterials 0210 nano-technology Antibacterial activity Pathogen Curing (chemistry) Bacteria |
| Zdroj: | ACS Biomaterials Science & Engineering. 5:2030-2040 |
| ISSN: | 2373-9878 |
| Popis: | The integration of nanomaterials with clinical therapeutic instruments is a promising approach to improve the effects of nanomaterials. We reported an efficient synergistic antibacterial strategy formed through the combination of Ag/ZnO nanocomposites with a light-emitting diode (LED) curing light, which is a commonly used small instrument in dental clinics. The as-designed integration depicted a significantly enhanced bactericidal effect on facultative anaerobic oral pathogen Streptococcus mutans (S. mutans) both in planktonic and biofilm phases over a very short irradiation time (≤5 min). Further study showed that the combination of LED and Ag/ZnO nanocomposites induced more ·OH and ·O2– generation, which is responsible for the enhanced antibacterial activity. Moreover, this combination could destroy S. mutans biofilm by killing the bacteria embedded within biofilm, inhibiting exopolysaccharide production and down-regulating the biofilm-related gene expression. Therefore, it is proposed that this combin... |
| Databáze: | OpenAIRE |
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