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Background: Hyperprolactinaemia impairs ovarian structural and functional development thereby causing anovulation and infertility. Immature coconut water (ICW) contains β-sitosterol known to be involved in the synthesis of steroid hormones in-vivo. Volume density (VD) evaluation of the ovarian follicular components has been used to measure the pattern of ovarian development and also to provide information on the physiological status of the ovaries. Thus, this study aimed to determine the effect of immature coconut water (ICW) on VD of the antrum, granulosa cell and theca cell of mature follicles in hyperprolactin rats treated with ICW.Material and Methods: A total of fifty- five (55) cyclic female Sprague-Dawley rats weighing 145-170 g were used for this study. The animals were randomly divided into four experimental study groups. Group 1 received distilled water only while group 2 rats were treated with metoclopramide hydrochloride (MCH) at 0.2 mg/100 g body weight for 28 days to induce hyperprolactinaemia and this was withdrawn for 8, 16 and 28 days to check for recovery. The animals in group 3 were post-treated with ICW for 8, 16 and 28 days and group 4, animals were treated with ICW only for 8, 16 and 28 days.Result: There were significant decreases in the VD of granulosa cell in the withdrawal groups when compared with the control. The VD of all cell types in the post-treated groups were statistically comparable with the control and the groups treated with immature coconut water only.Conclusion: Findings from this present study indicate that ICW stimulates follicular growth in hyperprolactin and control rats in the same pattern. |
