RETRACTED: Fluorescent sensing study and prevention ability on Alzheimer’s disease by reducing the oxidative stress injury in the nerve cells of two Zn(II) coordination polymers
| Autor: | Xiang-Hong Sun, Fang Cao, Ke Wang, Xiao-Na Wan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Stereochemistry
Coordination polymer 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Inorganic Chemistry chemistry.chemical_compound Materials Chemistry medicine Physical and Theoretical Chemistry Benzene Detection limit chemistry.chemical_classification Ligand Polymer 021001 nanoscience & nanotechnology Condensed Matter Physics Fluorescence 0104 chemical sciences Electronic Optical and Magnetic Materials chemistry Nerve cells Ceramics and Composites 0210 nano-technology Oxidative stress |
| Zdroj: | Journal of Solid State Chemistry. 288:121447 |
| ISSN: | 0022-4596 |
| DOI: | 10.1016/j.jssc.2020.121447 |
| Popis: | By using terphenyl-3,3″,5,5″-tetracarboxylic acid (H4tptc) ligand and different N-donor co-ligands, two Zn(II)-based coordination polymers (CPs) {[Zn(tptc)(1,2-bimb)2]·4.5(H2O)}n (1, 1,2-bimb = 1,2-bis (imidazol-1-ylmethyl) benzene) and {[Zn3(Htptc)2(2,2´-bpy)2]·1.5H2O}n (2, 2,2´-bpy = 2,2´-bipyridine) were prepared. Compound 1 could be used as a sensor for Fe3+ ion with a low detection limit. To develop novel candidates for Alzheimer’s disease (AD) treatment, ELISA detection kit was used to determine the Aβ 40 and Aβ 42 content produced in nerve cells. RT-PCR was carried out to measure the ROS related genes relative expression levels, for example, pg91 and gp21. |
| Databáze: | OpenAIRE |
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