| Autor: |
F. J. Wheeler, M. L. Griebenow, Patrick R. Gavin, René Huiskamp |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Advances in Neutron Capture Therapy ISBN: 9781461362968 |
| DOI: |
10.1007/978-1-4615-2978-1_119 |
| Popis: |
The macroscopic distribution of borocaptate sodium (Na2B12H11SH or BSH) in normal tissues has been determined and can be accurately predicted from the blood concentration.1,2 The compound para-borono-phenylalanine (p-BPA) has also been studied in dogs and normal tissue distribution has been determined.3 The total physical dose required to reach a biological isoeffect appears to increase directly as the proportion of boron capture dose increases.4 This effect, together with knowledge of the macrodistribution, led to estimates of the influence of the microdistribution of the BSH compound. This paper reports a computer model that was used to predict the compound factor for BSH and p-BPA and, hence, the equivalent radiation in normal tissues. The compound factor would need to be calculated for other compounds with different distributions. This information is needed to design appropriate normal tissue tolerance studies for different organ systems and/or different boron compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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