ChemInform Abstract: Novel Abietane Diterpenoids and Aromatic Compounds from Cladonia rangiferina and Their Antimicrobial Activity Against Antibiotics Resistant Bacteria

Autor:	Tatsuro Nakano, Toshihiro Hashimoto, Masami Tanaka, Kazuko Yoshikawa, Naoki Kokudo, Naokatsu Aragaki, Tomihiko Higuchi, Hirofumi Shibata
Rok vydání:	2008
Předmět:	biology Stereochemistry General Medicine biology.organism_classification medicine.disease_cause Antimicrobial Terpenoid Cladonia rangiferina Labdane Terpene chemistry.chemical_compound chemistry Staphylococcus aureus medicine Diterpene Abietane
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200828177
Popis:	From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Databáze:	OpenAIRE
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