Tricyclic antidepressant drugs and cardiac conduction
| Autor: | P. Dumovic, G D Burrows, Kay P. Maguire, Brian Davies, Jitendra K. Vohra, B. A. Scoggins |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
chemistry.chemical_classification
business.industry General Neuroscience Tricyclic antidepressant drugs General Medicine Plasma levels Pharmacology Doxepin Intracardiac injection Psychiatry and Mental health QRS complex chemistry Anesthesia Cardiac conduction medicine Pharmacology (medical) Nortriptyline General Pharmacology Toxicology and Pharmaceutics business medicine.drug Tricyclic |
| Zdroj: | Progress in Neuro-Psychopharmacology. 1:329-334 |
| ISSN: | 0364-7722 |
| DOI: | 10.1016/0364-7722(77)90058-3 |
| Popis: | 1. 1. Distal intracardiac conduction defects were observed inpatients ingesting both toxic and therapeutic doses of tricyclic antidepressants (TCA). 2. 2. In a crossover comparative study of doxepin-nortriptyline (150 mg/day for 3 weeks) six out of seventeen patients on nortriptyline and only one patient on doxepin showed significant prolongation of the QRS interval. 3. 3. Plasma levels of doxepin (52 ± 6 ng/ml) were lower than those of nortriptyline (196 ± 29 ng/ml). 4. 4. An in vitro study of TCA has shown that the isolated perfused guinea pig heart could provide a toxicological model for studying the arrhythmogenic effects of TCA in man. |
| Databáze: | OpenAIRE |
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