Household-Contact Investigation for Detection of Tuberculosis in Vietnam
| Autor: | Nghiem Le Phuong Hoa, Guy B. Marks, Phan T Lieu, Nguyen Thi Loi, Greg J. Fox, Warwick J. Britton, Dinh Ngoc Sy, Nguyen Viet Nhung, N. B. Hoa, Pham Duc Cuong, Nguyen Hoang Dung, Nguyen Thu Anh, Jessica Bestrashniy, Le T Nhung, Nguyen Kim Cuong, T. N. Buu, Nguyen Viet Hung, Le Thi Ngoc Anh |
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| Rok vydání: | 2018 |
| Předmět: |
education.field_of_study
Tuberculosis biology business.industry 030231 tropical medicine Population General Medicine biology.organism_classification medicine.disease law.invention Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Environmental health Local government medicine Sputum 030212 general & internal medicine Rural area medicine.symptom education business Contact tracing |
| Zdroj: | New England Journal of Medicine. 378:221-229 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background Active case finding is a top priority for the global control of tuberculosis, but robust evidence for its effectiveness in high-prevalence settings is lacking. We sought to evaluate the effectiveness of household-contact investigation, as compared with standard, passive measures alone, in Vietnam. Methods We performed a cluster-randomized, controlled trial at clinics in 70 districts (local government areas with an average population of approximately 500,000 in urban areas and 100,000 in rural areas) in eight provinces of Vietnam. Health workers at each district clinic or hospital were assigned to perform either household-contact intervention plus standard passive case finding (intervention group) or passive case finding alone (control group). In the intervention districts, household contacts of patients with positive results for tuberculosis on sputum smear microscopy (smear-positive tuberculosis) were invited for clinical assessment and chest radiography at baseline and at 6, 12, and ... |
| Databáze: | OpenAIRE |
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