Marked improvement in cardiovascular function after successful transsphenoidal surgery in acromegalic patients
| Autor: | Giuseppe Minniti, Antonio Santoro, C. Moroni, Giampaolo Cantore, Guido Tamburrano, Cesare Affricano, Vincenzo Esposito, Marie Lise Jaffrain-Rea, R. Cassone |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Transsphenoidal surgery
medicine.medical_specialty Ambulatory blood pressure medicine.diagnostic_test business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Hemodynamics Doppler echocardiography Pituitary neoplasm medicine.disease Endocrinology Blood pressure Internal medicine Acromegaly medicine Isovolumic relaxation time business |
| Zdroj: | Clinical Endocrinology. 55:307-313 |
| ISSN: | 0300-0664 |
| Popis: | OBJECTIVE Transsphenoidal surgery results in biochemical remission of acromegaly in 45–80% of patients; however, few studies have addressed the impact of transsphenoidal surgery on cardiovascular function in acromegalic patients. The aim of this prospective study was to investigate the effects of postoperative GH/IGF-I normalization on echocardiographic parameters and blood pressure (BP) in a series of patients with active acromegaly. DESIGN An open prospective study. PATIENTS Thirty newly diagnosed acromegalic patients undergoing transsphenoidal surgery. MEASUREMENTS Doppler echocardiography and 24-h ambulatory blood pressure monitoring were performed before and 6 months after transsphenoidal surgery. RESULTS Fifteen patients were considered to be well controlled postoperatively (group A), as defined by normal age-corrected IGF-I levels and glucose-suppressed GH levels less than 2 mU/l, the remaining 15 patients being considered as poorly controlled (group B). In group A, a postoperative decrease of left ventricular mass index was observed (104·4 ± 6·6 vs. 127·1 ± 7·7 g/m2; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text