| Autor: |
Katalin Balogh-Nemes, Zsuzsanna Niegreisz, Andrea Hrabéczy-Páll, George Horvai, Lajos Gödörházy, Antal Tolokán, Viola Horváth, Emilia Kocsi, Imre Klebovich |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Journal of Chromatography A. 771:35-43 |
| ISSN: |
0021-9673 |
| DOI: |
10.1016/s0021-9673(97)00186-6 |
| Popis: |
Economic automation of multistep analytical sample preparation is still a largely unsolved problem. Existing systems either handle only a few steps of a complex analytical scheme or they offer a complete solution at relatively high cost. This paper shows, using a rather general example that it is possible to construct a system in the analytical laboratory with an optimal balance between automating most steps of the analysis scheme and still keeping the costs of the system within bounds. A practical example from pharmacokinetic analysis is presented; pretreatment of blood plasma samples for nifedipine determination by high-performance liquid chromatography. The automated method involves steps such as aliquoting, pH adjustment, liquid-liquid extraction and evaporation to dryness. The system is built around a robotic arm from commercial equipment not designed originally for use with a robot. Analytical results and costs are compared to the manual method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect