Continuous Flow Aerobic Alcohol Oxidation Reactions Using a Heterogeneous Ru(OH)x/Al2O3 Catalyst

Autor:	David S. Mannel, Shannon S. Stahl, Thatcher W. Root
Rok vydání:	2014
Předmět:	Packed bed chemistry.chemical_compound chemistry Alcohol oxidation Yield (chemistry) Organic Chemistry Inorganic chemistry Indoline Dehydrogenation Methanol Physical and Theoretical Chemistry Toluene Catalysis
Zdroj:	Organic Process Research & Development. 18:1503-1508
ISSN:	1520-586X 1083-6160
Popis:	Ru(OH)x/Al2O3 is among the more versatile catalysts for aerobic alcohol oxidation and dehydrogenation of nitrogen heterocycles. Here, we describe the translation of batch reactions to a continuous-flow method that enables high steady-state conversion and single-pass yields in the oxidation of benzylic alcohols and dehydrogenation of indoline. A dilute source of O2 (8% in N2) was used to ensure that the reaction mixture, which employs toluene as the solvent, is nonflammable throughout the process. A packed bed reactor was operated isothermally in an up-flow orientation, allowing good liquid–solid contact. Deactivation of the catalyst during the reaction was modeled empirically, and this model was used to achieve high conversion and yield during extended operation in the aerobic oxidation of 2-thiophene methanol (99+% continuous yield over 72 h).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::23b78d92796dc891a3450dc490f1eda0 https://doi.org/10.1021/op5002676 Zobrazit plný text záznamu