Immunomodulation by morphine in -infected mice
| Autor: | Savita J. Singh, G.P. Dutta, Rikhab C. Srimal, Prati Pal Singh |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
biology
Ratón business.industry Low dose Long-term potentiation General Medicine (+)-Naloxone Pharmacology biology.organism_classification General Biochemistry Genetics and Molecular Biology In vitro Immunology Morphine Medicine Macrophage Plasmodium berghei General Pharmacology Toxicology and Pharmaceutics business medicine.drug |
| Zdroj: | Life Sciences. 54:331-339 |
| ISSN: | 0024-3205 |
| Popis: | The effect of morphine on immunomodulation and host defense have been investigated during Plasmodiumbergheiinfection in BALB/c mice. A single low (5.0 mg/kg) subcutaneous dose of morphine strongly suppressed (sometimes completely eliminated) the parasitaemia, whereas a high dose (80.0 mg/kg) exerted mild potentiating effect. Mice treated with the low dose showed a significant (p < 0.05) increase in the total number of circulating leukocytes, the number (pool-size) of peritoneal macrophages, and the phagocytic activity of peritoneal macrophages, invitro. Conversely, in mice treated with the high dose, all these parameters were diminished. Silica (3.0 mg/mouse), administered intravenously, abrogated the morphine-induced protective effects but did not affect its potentiation of the infection. Naloxone pretreatment (4.0 mg/kg) completely blocked the protective effects of morphine, suggesting the mediation via naloxone-sensitive opiate-receptors; paradoxically, it did not affect the potentiating effects. These observations indicate that morphine exerted a dose-dependent, biphasic effect on the course of P.bergheiinfection in mice, apparently by modulating the macrophage-mediated protective mechanisms. |
| Databáze: | OpenAIRE |
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