| Autor: |
Anastasia Koutalopoulou, Hang T.T. Phan, Florina Borca, James Batchelor, Trevor R.F. Smith, Andrew S Duncombe, Ying Teo, Matthew Stammers, Michael R. Ardern-Jones |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.10.19.20214015 |
| Popis: |
ObjectiveIt has been assumed that a significant proportion of COVID-19 patients show evidence of hyperinflammation of which secondary haemophagocytic lymphohistiocytosis (sHLH) is the most severe manifestation. To facilitate diagnosis of sHLH the HScore has been developed and validated. We set out to examine the prevalence of sHLH-like hyperinflammation in COVID-19.MethodsWe retrospectively examined HScore parameters in 626 COVID-19 cases admitted to our institute of which 567 were suitable for analysis and compared these to a cohort of confirmed infection associated sHLH cases. To account for missing data, we calculated the maximum possible HScore of the recorded parameters (%HScore).ResultsEarly measurement of HScore parameters (day -1 to 4 from diagnosis) strongly predicted the %HScore over the course of the admission (p ConclusionSurprisingly, these findings show that sHLH-type hyperinflammation is not prevalent in COVID-19, and %HScores do not predict outcome. Therefore, new algorithms are required to optimise case selection for clinical trials of targeted anti-inflammatory interventions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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