The Spirometric Efficacy of Once-Daily Dosing With Tiotropium in Stable COPD
| Autor: | Charles W. Serby, Theodore J. Witek, Richard Casaburi, Dick D. Briggs, James F. Donohue, Shailendra Menjoge |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry COPD medicine.diagnostic_test business.industry medicine.drug_class Tiotropium bromide Critical Care and Intensive Care Medicine medicine.disease Placebo respiratory tract diseases law.invention FEV1/FVC ratio Randomized controlled trial law Bronchodilator Anesthesia Multicenter trial Medicine Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 118:1294-1302 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.118.5.1294 |
| Popis: | Study objective To compare the bronchodilator efficacyand safety of tiotropium and placebo. Design A3-month, randomized, double-blind, placebo-controlled, multicentertrial. Setting Outpatient. Patients Four hundred seventy patients with stable COPD (meanFEV 1 = 38.6% predicted). Interventions Tiotropium 18 μg (N = 279) or placebo (N = 191) given once dailyvia a lactose-based dry-powder inhaler device. Measurementsand results Spirometry was evaluated on days 1, 8, 50, and 92.Data were expressed as the mean trough ( ie , beforemorning dose; 23 to 24 h after previous dose) and average responseobserved in the 3 h after the dose was received. Tiotropiumproduced significant improvement in trough FEV 1 and FVC,averaging 12% greater than baseline on day 8; these improvements weremaintained on days 50 and 92. The average postdose FEV 1 was16% greater than baseline on day 1 and 20% greater than baseline onday 92; FVC was 17% greater than baseline on day 1 and 19% greaterthan baseline on day 92. Tiotropium was significantly more effectivethan placebo in both trough and average FEV 1 and FVCresponse (p Conclusions These data demonstrate that tiotropium is asafe and effective once-daily anticholinergic bronchodilator and shouldprove useful as first-line maintenance therapy inCOPD. |
| Databáze: | OpenAIRE |
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