Microbial reduction of ethyl 2-oxo-4-phenylbutyrate. Searching for R-enantioselectivity. New access to the enalapril like ACE inhibitors

Autor:	O. A. C. Antunes, Paulo S. Bergo de Lacerda, Maria Antonieta Ferrara, Edson L. S. Lima, Ricardo B. Coelho, Selma Gomes Ferreira Leite, Joyce Benzaquem Ribeiro, Elba P. S. Bon
Rok vydání:	2006
Předmět:	biology Aqueous medium Pichia angusta Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Angiotensin-converting enzyme Catalysis Inorganic Chemistry Biochemistry Ethyl 2-oxo-4-phenylbutyrate biology.protein medicine Enalapril Physical and Theoretical Chemistry medicine.drug
Zdroj:	Tetrahedron: Asymmetry. 17:1186-1188
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2006.04.008
Popis:	Herein, different microorganisms were tested in the enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl (R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the (R)-enantiomer in 81% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::23948a23823096d7e59aa043da40b9c1 https://doi.org/10.1016/j.tetasy.2006.04.008 Zobrazit plný text záznamu Full Text from ScienceDirect