ChemInform Abstract: Palladium-Catalyzed Chemoselective Monoarylation of Hydrazides for the Synthesis of [1,2,4]Triazolo[4,3-a]pyridines

Autor:	Robert M. Rzasa, Dawei Zhang, Oliver R. Thiel, Michal Achmatowicz, Robert D. Larsen, Andreas Reichelt, James R. Falsey
Rok vydání:	2010
Předmět:	chemistry.chemical_element General Medicine Hydrazide medicine.disease Combinatorial chemistry Catalysis Acetic acid chemistry.chemical_compound chemistry Nitrogen atom Microwave irradiation medicine Dehydration Palladium
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201027148
Popis:	An efficient and convenient method for the synthesis of [1,2,4]triazolo[4,3-a]pyridines was exemplified by the synthesis of 20 analogues bearing a variety of substituents at the 3-position. The methodology involves a palladium-catalyzed addition of hydrazides to 2-chloropyridine, which occurs chemoselectively at the terminal nitrogen atom of the hydrazide, followed by dehydration in acetic acid under microwave irradiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::238d11aa80eef9fc8ea6e1d1eac478a4 https://doi.org/10.1002/chin.201027148 Zobrazit plný text záznamu Plný text