Structural characteristics of Gracilaria lemaneiformis oligosaccharides and their alleviation of dextran sulphate sodium-induced colitis by modulating the gut microbiota and intestinal metabolites in mice

Autor:	Hui-Min Duan, Xu-Ting Xie, Yang Liu, Kit-Leong Cheong, Li-Xin Zheng, Xian-Qiang Chen
Rok vydání:	2021
Předmět:	Gastrointestinal tract biology Chemistry Firmicutes Bacteroidetes General Medicine Gut flora Pharmacology biology.organism_classification medicine.disease Ulcerative colitis In vitro Functional food medicine Colitis Food Science
Zdroj:	Food & Function. 12:8635-8646
ISSN:	2042-650X 2042-6496
Popis:	Ulcerative colitis (UC) is a chronic lifetime disorder with a high incidence worldwide. A functional food-based method to prevent UC would be a good option for disease control. G. lemaneiformis oligosaccharides (GLOs) should have potent benefits for the gastrointestinal tract, based on in vitro fermentation assessed in our previous study. This study evaluated the therapeutic potential of GLOs in UC, as well as their possible mechanisms of action. The administration of GLOs was able to reduce the severity of dextran sulphate sodium-induced colitis by protecting mice from weight loss, reductions in colon length, inflammatory infiltration, and colon damage. Gut microbiota composition analysis showed that at the phylum level, GLOs could restore the composition of Bacteroidetes and decrease the level of Firmicutes. Consistently, it increased the contents of beneficial microbial metabolites and short-chain fatty acids in the mouse colitis model. In conclusion, GLOs could comprise a promising functional food strategy to alleviate UC symptoms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2385e4dab6a3cb192a5a60d2ecfb5ce3 https://doi.org/10.1039/d1fo01201k Zobrazit plný text záznamu