Fiber-based tissue identification for electrode placement in deep brain stimulation neurosurgery (Conference Presentation)
| Autor: | Martin Parent, Tigran Galstian, Younes Messaddeq, Léo Cantin, Michel Prud’homme, Nicolas P. Lapointe, Daniel Côté, Laurent Goetz, Damon DePaoli |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Optical fiber Deep brain stimulation Computer science medicine.medical_treatment Human brain Grey matter law.invention Identification (information) medicine.anatomical_structure law Brain stimulation Electrode medicine Fiber Neurosurgery Electrode placement Biomedical engineering |
| Zdroj: | Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation. |
| DOI: | 10.1117/12.2213353 |
| Popis: | Deep brain stimulation’s effectiveness relies on the ability of the stimulating electrode to be properly placed within a specific target area of the brain. Optical guidance techniques that can increase the accuracy of the procedure, without causing any additional harm, are therefore of great interest. We have designed a cheap optical fiber-based device that is small enough to be placed within commercially available DBS stimulating electrodes’ hollow cores and that is capable of sensing biological information from the surrounding tissue, using low power white light. With this probe we have shown the ability to distinguish white and grey matter as well as blood vessels, in vitro, in human brain samples and in vivo, in rats. We have also repeated the in vitro procedure with the probe inserted in a DBS stimulating electrode and found the results were in good agreement. We are currently validating a second fiber optic device, with micro-optical components, that will result in label free, molecular level sensing capabilities, using CARS spectroscopy. The final objective will be to use this data in real time, during deep brain stimulation neurosurgery, to increase the safety and accuracy of the procedure. |
| Databáze: | OpenAIRE |
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