Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes
| Autor: | Hana Malinska, Martina Hüttl, Ondrej Seda, Irena Markova, Ludmila Kazdova |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
High sucrose
medicine.medical_specialty Sucrose business.industry Endocrinology Diabetes and Metabolism medicine.disease Transcriptome chemistry.chemical_compound Endocrinology Insulin resistance Liver steatosis chemistry Internal medicine Internal Medicine medicine Genetic predisposition Prediabetes Metabolic syndrome business |
| Zdroj: | Diabetes. 67 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Both genetic predisposition and nutrition factors, such as high sucrose diet (HSD), are involved in the development of metabolic syndrome and insulin resistance. HSD can cause glucose intolerance and liver steatosis and exert hypertriglyceridemic effect. The aim of this study was to investigate the liver transcriptome profile under standard diet or HSD (70 kcal% as sucrose) in two strains of rats. We used Wistar rats and a strain of hereditary hypertriglyceridemic rats (HHTg) as a polygenic model of metabolic syndrome and insulin resistance. HSD feeding in 2 weeks did not affect body weight, but fasting glucose and AUC were increased (P diet Disclosure I. Marková: None. M. Hüttl: None. H. Malinska: None. O. Seda: None. L. Kazdova: None. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|