Biodistribution of the photosensitizer dihaematoporphyrin ether

Autor:	Anthony L. Imbembo, Stephen Holt, James Persky, Marc L. Eckhauser, Jose Crespin, Anthony Bonaminio
Rok vydání:	1987
Předmět:	Kidney Biodistribution medicine.medical_treatment Spleen Ether Photodynamic therapy Dermatology Pharmacology Blood proteins chemistry.chemical_compound medicine.anatomical_structure chemistry Biochemistry Pharmacokinetics medicine Surgery Photosensitizer
Zdroj:	Lasers in Medical Science. 2:101-105
ISSN:	1435-604X 0268-8921
DOI:	10.1007/bf02594144
Popis:	Prior investigations describing the biodistribution of haematoporphyrin derivative (HpD) failed to substantiate a tumour-specific localization. Earlier optimism that dihaematoporphyrin ether (DHE), the active component of HpD, would demonstrate tumour specificity has also failed to be substantiated. The major sites of deposition for DHE are the same as those for HpD (liver, kidney and spleen) while the remaining organs show varying accumulation of DHE, depending on the dose given. Smaller doses of DHE, however, result in biodistribution patterns similar to those for HpD. The pharmacokinetics suggest that DHE binds to plasma proteins and, to some extent, to tissue. The optimal time for photodynamic therapy appears to be between 48 and 72 hours since the greatest mean tumour:muscle concentrations are found during this period.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::236d67bc7710adb8a48f80a98654bbe4 https://doi.org/10.1007/bf02594144 Zobrazit plný text záznamu Full text from SpringerLink