Five-coordinate aminophosphine platinum(II) complexes containing cysteine derivatives as ligands

Autor:	Piedad del Socorro Murdoch, M. Inés García-Seijo, Robert O. Gould, M. Esther García-Fernández, Abraha Habtemariam
Rok vydání:	2002
Předmět:	Phosphine oxide chemistry.chemical_classification Chemistry Stereochemistry chemistry.chemical_element Glutathione Tripeptide Adduct Inorganic Chemistry Trigonal bipyramidal molecular geometry chemistry.chemical_compound Materials Chemistry Thiol Physical and Theoretical Chemistry Platinum Cysteine
Zdroj:	Inorganica Chimica Acta. 335:52-60
ISSN:	0020-1693
Popis:	The platinum(II) complex, [Pt(NP3)Cl]Cl (1) [NP3=N(CH2CH2PPh2)3] reacts with thiol-containing biomolecules such as N-acetyl- l -cysteine (N-Ac- l -CysH) and the tripeptide reduced glutathione (γ- l -Glu- l -Cys-Gly, GSH) to afford the intensely-coloured five-coordinate complexes, [Pt(NP3)(N-Ac- l -Cys-S)] (2) and [Pt(NP3)(GS-S)] (3), respectively. Complex 2 was shown by X-ray crystallography to be trigonal bipyramidal and contained an axial PtS bond trans to N, the first example of such a complex. Coordination to Pt(II) protected the thiol from oxidation: reactions of complexes 2 and 3 with H2O2 gave the four-coordinate complexes [Pt(NP(O)P2)(SR-S)] (4, SR=N-Ac- l -Cys; 5, SR=GS) which possess a dangling arm phosphine oxide group. The thiolate adducts 2 and 3 exhibited low toxicity to cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::236d6560af281a3af56c70b82dbb45c4 https://doi.org/10.1016/s0020-1693(02)00813-7 Zobrazit plný text záznamu Full Text from ScienceDirect